Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 17/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479102 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1CYP2D6CYP3A4TSHR | |
| SCHEMBL6479105 | 1.00 | OPRK1 (1.00) | OPRK1OPRD1CYP2D6CYP3A4TSHR | |
| SCHEMBL8097254 | 0.96 | OPRK1 (0.92) | OPRK1OPRD1CYP2D6CYP3A4TSHR | |
| SCHEMBL6478689 | 0.88 | OPRK1 (1.00) | OPRK1OPRD1CYP2D6CYP3A4TSHR | |
| SCHEMBL6478692 | 0.88 | OPRK1 (1.00) | OPRK1OPRD1CYP2D6CYP3A4TSHR | |
| SCHEMBL17873664 | 0.87 | OPRK1 (1.00) | OPRK1OPRD1CYP2D6 | |
| SCHEMBL17873667 | 0.87 | OPRK1 (1.00) | OPRK1OPRD1CYP2D6 | |
| SCHEMBL5629426 | 0.86 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL9510585 | 0.86 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL17873644 | 0.84 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112252-A4 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | ADOLOR CORP (US) | 2004-07-14 | — | — | EP | claimed |
| EP-1112252-A1 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | Adolor Corporation (US) | 2001-07-04 | — | — | EP | claimed |
| WO-2000014065-A1 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | ADOLOR CORPORATION (US) | 2000-03-16 | — | — | WO | claimed |