Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 14/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596614 | 0.92 | CNR2 (0.53) | CNR2CNR1ESR1ESR2ATM | |
| SCHEMBL7446215 | 0.90 | CNR2 (0.51) | CNR2CNR1ESR1ESR2 | |
| SCHEMBL6597487 | 0.85 | ESR1 (0.58) | CNR2CNR1ESR1ESR2HSD17B1 | |
| SCHEMBL6592398 | 0.85 | CNR1 (0.70) | CNR2CNR1ESR1ESR2ATM | |
| SCHEMBL6595716 | 0.83 | CNR1 (0.55) | CNR2CNR1ESR1ESR2ATM | |
| SCHEMBL11552702 | 0.81 | CNR1 (0.64) | CNR2CNR1ESR1ESR2TDP1 | |
| SCHEMBL11547449 | 0.81 | CNR1 (0.64) | CNR2CNR1ESR1ESR2ATM | |
| SCHEMBL11553455 | 0.80 | CNR1 (0.68) | CNR2CNR1ESR1ESR2 | |
| SCHEMBL11548512 | 0.80 | CNR1 (0.71) | CNR2CNR1ESR1ESR2ATM | |
| SCHEMBL11554603 | 0.79 | ESR1 (0.64) | CNR2CNR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863755-B1 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 2004-12-15 | — | — | EP | disclosed |
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |