Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL986792 | 0.92 | AGTR1 (0.62) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| Hydrochloric Acid SCHEMBL7305266 | 0.91 | AGTR1 (0.62) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL1444914 | 0.90 | AGTR1 (0.54) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL6605154 | 0.89 | AGTR1 (0.64) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL683727 | 0.86 | AGTR1 (0.58) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL668336 | 0.86 | AGTR1 (0.57) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7886344 | 0.84 | AGTR1 (0.53) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7308359 | 0.84 | AGTR1 (0.53) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL9254924 | 0.84 | AGTR1 (0.57) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL16327937 | 0.84 | AGTR1 (0.61) | AGTR1AGTR2ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1110551-B1 | Ocular tension lowering agent | SANKYO CO (JP) | 2004-05-12 | — | — | EP | disclosed |
| EP-0795326-B1 | OCULAR TENSION DEPRESSANT | SANKYO CO (JP) | 2001-09-26 | — | — | EP | disclosed |
| EP-1110551-A2 | Ocular tension lowering agent | Sankyo Company Limited (JP) | 2001-06-27 | — | — | EP | disclosed |
| EP-0795326-A1 | OCULAR TENSION DEPRESSANT | SANKYO COMPANY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |