Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598732 | 0.90 | CCR2 (0.73) | CCR2ABCB11 | |
| SCHEMBL6599157 | 0.90 | CCR2 (0.66) | CCR2KMT2AMAPTTP53ABCB11 | |
| SCHEMBL6598129 | 0.89 | CCR2 (0.64) | CCR2KMT2AMAPTTP53ABCB11 | |
| SCHEMBL6357264 | 0.85 | CCR2 (0.65) | CCR2KMT2AMAPTABCB11 | |
| SCHEMBL6596843 | 0.83 | CCR2 (0.65) | CCR2KMT2AMAPTABCB11F10 | |
| SCHEMBL6300567 | 0.83 | CCR2 (0.67) | CCR2KMT2AMAPTABCB11 | |
| SCHEMBL6598096 | 0.83 | CCR2 (0.62) | CCR2KMT2AMAPTABCB11F10 | |
| SCHEMBL6591932 | 0.83 | CCR2 (0.64) | CCR2KMT2AMAPTABCB11F10 | |
| SCHEMBL6598132 | 0.81 | CCR2 (0.64) | CCR2KMT2AMAPTABCB11F10 | |
| SCHEMBL6302533 | 0.81 | CCR2 (0.63) | CCR2KMT2AMAPTABCB11F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |