SCHEMBL6598208

SCHEMBL6598208

CCOCCn1c(N2CCCN(CCC(CN(C)C(=O)c3cc(-n4cnnn4)ccc3OC)c3ccc(F)cc3)CC2)nc2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.37
HRH1 P35367 1/20 0.37
KCNH2 Q12809 1/20 0.37
TACR2 P21452 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6597713 0.94 CHRM1 (0.33) CHRM1HRH1KCNH2TACR2
SCHEMBL6598788 0.93 TACR2 (0.34) TACR2
SCHEMBL6593690 0.93 DRD2 (0.36) TACR2
SCHEMBL6596278 0.92 TACR2 (0.44) TACR2
SCHEMBL6594885 0.92 HRH1 (0.41) CHRM1HRH1KCNH2TACR2
SCHEMBL6596468 0.92 TACR2 (0.34) CHRM1HRH1KCNH2TACR2
SCHEMBL6597082 0.91 MEN1 (0.34) CHRM1HRH1TACR2
SCHEMBL6598377 0.91 TACR2 (0.34) CHRM1HRH1KCNH2TACR2
SCHEMBL6598374 0.91 TACR2 (0.34) CHRM1HRH1KCNH2TACR2
SCHEMBL6599290 0.89 MAPT (0.34) CHRM1HRH1KCNH2TACR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888338-B1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES AVENTIS PHARMA INC (US) 2004-11-17 EP disclosed
EP-0912556-A1 INDOLINE DERIVATIVES USEFUL AS 5-HT-2C RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-05-06 EP disclosed
EP-0888338-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
WO-1997048700-A1 INDOLINE DERIVATIVES USEFUL AS 5-HT-2C RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-12-24 WO disclosed
WO-1997030991-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed