Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 14/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR1F | P30939 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598690 | 1.00 | UTS2R (0.38) | UTS2RSLC6A2SLC6A4KCNH2PDE4A | |
| SCHEMBL6599108 | 0.90 | MAPK1 (0.39) | UTS2RSLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL6599020 | 0.87 | F10 (0.36) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL6598734 | 0.87 | F10 (0.36) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL6598651 | 0.83 | SLC6A2 (0.34) | SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL6598659 | 0.83 | UTS2R (0.39) | UTS2RSLC6A2SLC6A4KCNH2PDE4A | |
| SCHEMBL6599636 | 0.82 | F10 (0.36) | — | |
| SCHEMBL7143855 | 0.82 | SLC6A2 (0.40) | UTS2RSLC6A2SLC6A4KCNH2HTR1A | |
| SCHEMBL6600072 | 0.82 | F10 (0.35) | SLC6A2SLC6A4 | |
| SCHEMBL7140946 | 0.79 | SLC6A2 (0.40) | UTS2RSLC6A2SLC6A4KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |