Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 12/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599112 | 0.90 | MAPK1 (0.42) | UTS2RSLC6A2SLC6A4KCNH2MAPK1 | |
| SCHEMBL6598738 | 0.86 | F10 (0.38) | SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL6598656 | 0.83 | UTS2R (0.38) | UTS2RSLC6A2SLC6A4PDE4APDE4B | |
| SCHEMBL6598690 | 0.83 | UTS2R (0.38) | UTS2RSLC6A2SLC6A4PDE4APDE4B | |
| SCHEMBL6599638 | 0.82 | F10 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL6598653 | 0.82 | SLC6A2 (0.36) | SLC6A2SLC6A4KCNH2MAPK1CYP2D6 | |
| SCHEMBL7143857 | 0.81 | SLC6A2 (0.43) | UTS2RSLC6A2SLC6A4KCNH2HTR1A | |
| SCHEMBL6600076 | 0.81 | F10 (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL6603094 | 0.78 | SLC6A2 (0.34) | SLC6A2SLC6A4KCNH2MAPK1CYP2D6 | |
| SCHEMBL6979203 | 0.78 | SLC6A2 (0.43) | UTS2RSLC6A2SLC6A4KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| EP-1379503-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002079155-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |