Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990985 | 0.94 | KDR (0.52) | FGFR1KDRPDGFRBEGFRSRC | |
| SCHEMBL4990992 | 0.94 | KDR (0.52) | FGFR1KDRPDGFRBEGFRSRC | |
| SCHEMBL4995141 | 0.90 | ALDH1A1 (0.48) | FGFR1KDRPDGFRBSRCFLT1 | |
| SCHEMBL4995145 | 0.90 | ALDH1A1 (0.48) | FGFR1KDRPDGFRBSRCFLT1 | |
| SCHEMBL4997207 | 0.88 | KDR (0.56) | FGFR1KDRPDGFRBEGFRSRC | |
| SCHEMBL4997208 | 0.88 | KDR (0.56) | FGFR1KDRPDGFRBEGFRSRC | |
| SCHEMBL6610565 | 0.87 | ZAP70 (0.44) | FGFR1KDRPDGFRBEGFRFLT1 | |
| SCHEMBL6610571 | 0.87 | ZAP70 (0.44) | FGFR1KDRPDGFRBEGFRFLT1 | |
| SCHEMBL4991358 | 0.84 | KDR (0.50) | FGFR1KDRPDGFRBSRCFLT1 | |
| SCHEMBL4991346 | 0.84 | KDR (0.50) | FGFR1KDRPDGFRBSRCFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |