Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.72 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | XDH | P47989 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | CFD | P00746 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406972 | 0.90 | FLT3 (0.70) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL18733286 | 0.89 | KDM4E (0.79) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL710398 | 0.88 | KDM4E (0.73) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL13133298 | 0.87 | KDM4E (0.81) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL630515 | 0.87 | SRD5A2 (1.00) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5114489 | 0.86 | KDM4E (0.75) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6089719 | 0.85 | KDM4E (0.81) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL18900668 | 0.84 | KDM4E (0.75) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6870759 | 0.84 | PDGFRB (1.00) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL7066092 | 0.83 | FLT3 (0.78) | KDM4ESRD5A2ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| CN-1339025-A | Indole derivatives and their use as MCP-1 antagonists | ASTRAZENECA AB (SE) | 2002-03-06 | — | — | CN | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |