Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CFD | P00746 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599162 | 0.86 | KDM4E (0.77) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL13133298 | 0.86 | KDM4E (0.81) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL630515 | 0.86 | SRD5A2 (1.00) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL31159466 | 0.84 | KDM4E (0.66) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL6089719 | 0.84 | KDM4E (0.81) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7097103 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7877462 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL18900668 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| Hydrochloric Acid SCHEMBL7873343 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL4460774 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468380-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-12-23 | — | — | US | disclosed |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-01-04 | — | — | US | disclosed |
| US-7109219-B2 | Nitrogen-containing aromatic derivatives | EISAI CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-01-05 | — | — | US | disclosed |
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1522540-A1 | AZAARENE DERIVATIVES | Eisai Co., Ltd. (JP) | 2005-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | KDM4E 2341/4885ALDH1A1 1501/4885CYP1A2 81/4885 |
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | KDM4E 2341/4885ALDH1A1 1501/4885CYP1A2 81/4885 |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | KDM4E 2341/4885ALDH1A1 1501/4885CYP1A2 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.