Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596058 | 0.91 | MAPT (0.53) | MAPTTHRBCCR2MTNR1AMTNR1B | |
| SCHEMBL6595874 | 0.91 | CCR2 (0.61) | CCR2MTNR1AMTNR1BMCL1F10 | |
| SCHEMBL6775247 | 0.87 | CCR2 (0.65) | MAPTTHRBCCR2MTNR1AMTNR1B | |
| SCHEMBL7234016 | 0.84 | MAPT (0.55) | MAPTTHRBCCR2MTNR1AMTNR1B | |
| SCHEMBL6599254 | 0.82 | MAPT (0.56) | MAPTTHRBCCR2MTNR1AMTNR1B | |
| SCHEMBL6596946 | 0.81 | MAPT (0.59) | MAPTTHRBKMT2AALDH1A1GAA | |
| SCHEMBL6596843 | 0.80 | CCR2 (0.65) | MAPTCCR2KMT2AF10 | |
| SCHEMBL6591932 | 0.79 | CCR2 (0.64) | MAPTCCR2KMT2AF10 | |
| SCHEMBL6598132 | 0.79 | CCR2 (0.64) | MAPTCCR2KMT2AF10 | |
| SCHEMBL6594219 | 0.79 | CCR2 (0.57) | CCR2MTNR1AMTNR1BMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |