Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599490 | 1.00 | FLT3 (0.39) | FLT3PDGFRBRETERBB2ALDH1A1 | |
| SCHEMBL4997248 | 0.94 | RET (0.41) | FLT3PDGFRBRETERBB2ALDH1A1 | |
| SCHEMBL4997253 | 0.94 | RET (0.41) | FLT3PDGFRBRETERBB2ALDH1A1 | |
| SCHEMBL4990826 | 0.94 | PAK1 (0.39) | FLT3ALDH1A1CRHBPHTTCRHR2 | |
| SCHEMBL4990835 | 0.94 | PAK1 (0.39) | FLT3ALDH1A1CRHBPHTTCRHR2 | |
| SCHEMBL4994178 | 0.88 | ALDH1A1 (0.42) | FLT3ALDH1A1CRHBPHTTCRHR2 | |
| SCHEMBL4994729 | 0.88 | HRH1 (0.45) | FLT3PDGFRBRETERBB2ALDH1A1 | |
| SCHEMBL4994170 | 0.88 | ALDH1A1 (0.42) | FLT3ALDH1A1CRHBPHTTCRHR2 | |
| SCHEMBL4994734 | 0.88 | HRH1 (0.45) | FLT3PDGFRBRETERBB2ALDH1A1 | |
| SCHEMBL4988148 | 0.85 | RET (0.51) | FLT3PDGFRBRETERBB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |