Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 19/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489842 | 1.00 | OPRK1 (0.62) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 | |
| SCHEMBL6489839 | 1.00 | OPRK1 (0.62) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 | |
| Hydrochloric Acid SCHEMBL6490441 | 0.91 | OPRK1 (0.67) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 | |
| SCHEMBL6480226 | 0.89 | OPRK1 (0.60) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL6480228 | 0.89 | OPRK1 (0.60) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL8100469 | 0.88 | OPRK1 (0.59) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL6479301 | 0.81 | OPRK1 (0.57) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 | |
| SCHEMBL5629391 | 0.81 | OPRK1 (0.72) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 | |
| SCHEMBL6478177 | 0.80 | OPRK1 (0.71) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 | |
| SCHEMBL8197775 | 0.79 | OPRK1 (0.73) | OPRK1CYP2D6OPRM1OPRD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112252-A4 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | ADOLOR CORP (US) | 2004-07-14 | — | — | EP | claimed |
| EP-1112252-A1 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | Adolor Corporation (US) | 2001-07-04 | — | — | EP | claimed |
| WO-2000014065-A1 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | ADOLOR CORPORATION (US) | 2000-03-16 | — | — | WO | claimed |