Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035120 | 0.84 | GSK3B (0.66) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL6035526 | 0.79 | GSK3B (0.71) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL27754747 | 0.72 | PRKCI (0.64) | GAAHPGDPRKCINPC1LMNA | |
| SCHEMBL6599715 | 0.71 | HRH3 (0.45) | MCHR1HRH3DYRK1AUSP30 | |
| Hydrochloric Acid SCHEMBL27606635 | 0.71 | PRKCI (0.63) | GAAHPGDPRKCINPC1LMNA | |
| SCHEMBL6034162 | 0.70 | GSK3B (0.67) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL3333340 | 0.69 | HRH3 (0.61) | MCHR1HRH3USP30 | |
| SCHEMBL17888295 | 0.68 | MCHR1 (0.61) | MCHR1HRH3USP30 | |
| SCHEMBL6033920 | 0.67 | ATR (0.85) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL31654003 | 0.66 | HRH3 (0.50) | MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | claimed |