Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599713 | 0.71 | MCHR1 (0.45) | HRH3MCHR1USP30DYRK1A | |
| SCHEMBL3333340 | 0.71 | HRH3 (0.61) | HRH3MCHR1USP30CCR5 | |
| SCHEMBL31654003 | 0.71 | HRH3 (0.50) | HRH3MCHR1CCR5 | |
| SCHEMBL17888295 | 0.70 | MCHR1 (0.61) | HRH3MCHR1USP30 | |
| SCHEMBL2850737 | 0.68 | KDM4E (0.53) | ALDH1A1 | |
| SCHEMBL17886695 | 0.67 | MCHR1 (0.65) | HRH3MCHR1USP30 | |
| SCHEMBL21214422 | 0.67 | MCHR1 (0.64) | HRH3MCHR1USP30CCR5 | |
| SCHEMBL28506326 | 0.67 | MCHR1 (0.58) | HRH3MCHR1USP30CCR5 | |
| Trifluoroacetic Acid SCHEMBL28780856 | 0.65 | MCHR1 (0.59) | HRH3MCHR1USP30CCR5 | |
| SCHEMBL25498560 | 0.65 | LMNA (0.65) | HRH3MCHR1USP30ALDH1A1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | claimed |