Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.42 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22911613 | 0.84 | CYP19A1 (0.54) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL29956130 | 0.81 | CYP19A1 (0.51) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL3126133 | 0.81 | CYP19A1 (0.51) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL6947317 | 0.80 | CYP19A1 (0.54) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL9592639 | 0.80 | CYP19A1 (0.54) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL763418 | 0.80 | CYP1A2 (0.55) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL31472893 | 0.80 | CYP19A1 (0.54) | CYP19A1TBXAS1ROCK2ROCK1MYLK4 | |
| SCHEMBL5801109 | 0.80 | CYP19A1 (0.54) | CYP19A1TBXAS1ROCK2ROCK1MYLK4 | |
| SCHEMBL3144694 | 0.80 | CYP19A1 (0.54) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 | |
| SCHEMBL3825275 | 0.80 | CYP19A1 (0.54) | CYP19A1TBXAS1PDE10AIMPDH2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |