SCHEMBL29956130

SCHEMBL29956130

O=CCc1ccc2cnccc2c1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.51
TBXAS1 P24557 1/20 0.44
PDE10A Q9Y233 1/20 0.41
IMPDH2 P12268 3/20 0.40
CYP3A4 P08684 2/20 0.40
CCNT1 O60563 1/20 0.40
CDK9 P50750 1/20 0.40
HASPIN Q8TF76 1/20 0.40
PRMT3 O60678 2/20 0.39
CYP2A6 P11509 2/20 0.39
ROCK2 O75116 2/20 0.39
ROCK1 Q13464 1/20 0.39
MYLK4 Q86YV6 1/20 0.39
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3126133 1.00 CYP19A1 (0.51) CYP19A1TBXAS1PDE10AIMPDH2CYP3A4
SCHEMBL1401429 0.93 CYP19A1 (0.51) CYP19A1TBXAS1PDE10AIMPDH2CCNT1
SCHEMBL29952031 0.93 CYP19A1 (0.51) CYP19A1TBXAS1PDE10AIMPDH2CCNT1
SCHEMBL6599732 0.81 CYP19A1 (0.54) CYP19A1TBXAS1PDE10AIMPDH2CYP3A4
SCHEMBL19796376 0.77 IMPDH2 (0.44) CYP19A1IMPDH2CYP3A4PRMT3ROCK2
SCHEMBL9592639 0.77 CYP19A1 (0.54) CYP19A1TBXAS1PDE10AIMPDH2PRMT3
SCHEMBL3825275 0.77 CYP19A1 (0.54) CYP19A1TBXAS1PDE10AIMPDH2PRMT3
SCHEMBL5801109 0.77 CYP19A1 (0.54) CYP19A1TBXAS1CYP2A6ROCK2ROCK1
SCHEMBL22911613 0.77 CYP19A1 (0.54) CYP19A1TBXAS1PDE10AIMPDH2HASPIN
SCHEMBL3144694 0.77 CYP19A1 (0.54) CYP19A1TBXAS1PDE10AIMPDH2HASPIN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed