Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.74 |
| ▸ | CDK4 | P11802 | 13/20 | 0.74 |
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599784 | 0.88 | CDK2 (0.76) | CDK2CDK4EIF2AK2 | |
| SCHEMBL4615032 | 0.86 | CDK2 (0.77) | CDK2CDK4EIF2AK2CCNE1AURKA | |
| SCHEMBL4616002 | 0.86 | CDK2 (1.00) | CDK2CDK4EIF2AK2 | |
| SCHEMBL4613384 | 0.84 | CDK2 (1.00) | CDK2CDK4EIF2AK2 | |
| SCHEMBL6597467 | 0.81 | CDK2 (0.73) | CDK2CDK4EIF2AK2CCNE1AURKA | |
| SCHEMBL4615719 | 0.77 | CDK4 (1.00) | CDK2CDK4EIF2AK2AURKB | |
| SCHEMBL6600528 | 0.76 | CDK2 (0.50) | CDK2CDK4EIF2AK2PARP1CCNE1 | |
| SCHEMBL8317316 | 0.75 | CDK2 (0.74) | CDK2CDK4EIF2AK2 | |
| SCHEMBL4615069 | 0.75 | CDK4 (0.80) | CDK2CDK4EIF2AK2 | |
| SCHEMBL4613411 | 0.74 | CDK2 (0.78) | CDK2CDK4EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373253-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | Cyclacel Limited (GB) | 2004-01-02 | — | — | EP | claimed |
| WO-2002079193-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | CYCLACEL LIMITED (GB) | 2002-10-10 | — | — | WO | claimed |