Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.48 |
| ▸ | GBA1 | P04062 | 8/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | GBA2 | Q9HCG7 | 11/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10590808 | 0.98 | S1PR1 (0.49) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL3428819 | 0.98 | S1PR1 (0.49) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL2850065 | 0.96 | S1PR1 (0.47) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL4229106 | 0.91 | GBA2 (0.46) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL3265496 | 0.91 | S1PR1 (0.50) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| Pyrrolidine SCHEMBL4393172 | 0.87 | GBA1 (0.43) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL28123990 | 0.85 | GBA2 (0.47) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL27675556 | 0.83 | GBA1 (0.43) | S1PR1S1PR3S1PR5GBA1GAA | |
| SCHEMBL19126196 | 0.78 | CXCR4 (0.50) | S1PR1S1PR3S1PR5GBA1S1PR4 | |
| SCHEMBL14079463 | 0.78 | CXCR4 (0.50) | S1PR1S1PR3S1PR5GBA1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905132-B1 | Benzothiophenes | LILLY CO ELI (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6060488-A | ANTICARCINOGENIC AGENTS; POSTMENOPAUSAL CANCER OF BREASTS, UTERUS, CERVIX | ELI LILLY AND COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| WO-1999015521-A1 | BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1999-04-01 | — | — | WO | disclosed |
| EP-0905132-A1 | Benzothiophenes | ELI LILLY AND COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |