Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | GBA2 | Q9HCG7 | 9/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850065 | 0.90 | S1PR1 (0.47) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL10590808 | 0.89 | S1PR1 (0.49) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL3428819 | 0.89 | S1PR1 (0.49) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| Methane SCHEMBL6600535 | 0.87 | S1PR1 (0.48) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL4229106 | 0.85 | GBA2 (0.46) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL3265496 | 0.85 | S1PR1 (0.50) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL28123990 | 0.79 | GBA2 (0.47) | GBA1S1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL27675556 | 0.77 | GBA1 (0.43) | GBA1S1PR1S1PR3S1PR5GAA | |
| SCHEMBL3255618 | 0.75 | GNAO1 (0.42) | GBA1GNAO1GNAI3GNAI1S1PR1 | |
| SCHEMBL23865736 | 0.73 | SPHK2 (0.58) | GBA1S1PR1S1PR3S1PR5S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099454-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | Abbott Laboratories (US) | 2009-09-16 | — | — | EP | disclosed |
| CN-101534824-A | Aminopyrrolidines as chemokine receptor antagonists | ABBOTT LAB (US) | 2009-09-16 | — | — | CN | disclosed |
| WO-2008060621-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |