Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582371 | 0.94 | NPC1 (0.49) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| SCHEMBL6602100 | 0.94 | MAOB (0.48) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7646213 | 0.93 | MAOB (0.47) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL146882 | 0.92 | MAPK1 (0.46) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| SCHEMBL6581923 | 0.92 | NPC1 (0.48) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| Hydrochloric Acid SCHEMBL7652761 | 0.92 | MAPK1 (0.45) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| SCHEMBL6603283 | 0.92 | ALDH1A1 (0.43) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| SCHEMBL6585175 | 0.91 | ALDH1A1 (0.51) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| SCHEMBL6581799 | 0.91 | NPC1 (0.45) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 | |
| SCHEMBL6583333 | 0.91 | KMT2A (0.49) | SMN1; SMN2KMT2ANPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |