Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 9/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935691 | 0.84 | PPARA (0.61) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL8935696 | 0.84 | PPARA (0.61) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL1245354 | 0.83 | PPARA (0.60) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL2210931 | 0.82 | TSHR (0.66) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL4816920 | 0.82 | PPARA (0.59) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL2597640 | 0.82 | TSHR (0.66) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL5861893 | 0.81 | PPARA (0.57) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL5860631 | 0.79 | PPARA (0.56) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| Dimethylamine SCHEMBL28258492 | 0.78 | TSHR (0.61) | PPARASMN1; SMN2PPARGPTGDR2TSHR | |
| SCHEMBL5861853 | 0.78 | SMN1; SMN2 (0.62) | PPARASMN1; SMN2PPARGPTGDR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046350-A1 | NOVEL COMPOUNDS, THEIR PREPARATION AND USE | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-02-23 | — | — | US | disclosed |
| EP-2386540-A1 | Novel compounds, their preparation and use | High Point Pharmaceuticals, LLC (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110245244-A1 | PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-10-06 | — | — | US | disclosed |
| US-20110184186-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2011-07-28 | — | — | US | disclosed |
| US-7982050-B2 | Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2011-07-19 | — | — | US | disclosed |
| US-7968723-B2 | Compounds, their preparation and use | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-06-28 | — | — | US | disclosed |
| US-7943613-B2 | Compounds, their preparation and use | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-05-17 | — | — | US | disclosed |
| US-20110039841-A1 | Novel compounds, their preparation and use | NOVO NORDISK A/S (DK) | 2011-02-17 | — | — | US | disclosed |
| US-20100210653-A1 | Novel Compounds, Their Preparations and Use | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-08-19 | — | — | US | disclosed |
| US-7129268-B2 | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives | NOVO NORDISK A/S (DK) | 2006-10-31 | — | — | US | disclosed |
| US-7091237-B2 | Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050070583-A1 | Novel compounds, their preparation and use | VTVX HOLDINGS II LLC | 2005-03-31 | — | — | US | disclosed |
| US-20040157890-A1 | Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors | GLAXO GROUP LIMITED (GB) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039841-A1 | Novel compounds, their preparation and use | PPARG, PPARD, PPARA | PPARA 3/4885SMN1; SMN2 4002/4885PPARG 1/4885 |
| US-20110184186-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | PPARG, PPARD, PPARA | PPARA 3/4885SMN1; SMN2 4828/4885PPARG 1/4885 |
| US-20040157890-A1 | Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors | PPARG, PPARD, PPARA | PPARA 3/4885SMN1; SMN2 3688/4885PPARG 1/4885 |
| US-20050070583-A1 | Novel compounds, their preparation and use | PPARG, PPARD, PPARA | PPARA 3/4885SMN1; SMN2 2907/4885PPARG 1/4885 |
| US-20100210653-A1 | Novel Compounds, Their Preparations and Use | PPARG, PPARD, PPARA | PPARA 3/4885SMN1; SMN2 2610/4885PPARG 1/4885 |
| US-20120046350-A1 | NOVEL COMPOUNDS, THEIR PREPARATION AND USE | PPARG, PPARD, PPARA | PPARA 3/4885SMN1; SMN2 2907/4885PPARG 1/4885 |
| US-20110245244-A1 | PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS | PPARG, PPARA, PPARD | PPARA 2/4885SMN1; SMN2 4759/4885PPARG 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.