Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | PPARA | Q07869 | 7/20 | 0.55 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935691 | 0.81 | PPARA (0.61) | SMN1; SMN2PPARAPPARGKDM4EPTGDR2 | |
| SCHEMBL8935696 | 0.81 | PPARA (0.61) | SMN1; SMN2PPARAPPARGKDM4EPTGDR2 | |
| SCHEMBL5861893 | 0.80 | PPARA (0.57) | SMN1; SMN2PPARAPPARGPTGDR2TSHR | |
| SCHEMBL1245354 | 0.80 | PPARA (0.60) | SMN1; SMN2PPARAPPARGPTGDR2TSHR | |
| SCHEMBL660084 | 0.78 | PPARA (0.59) | SMN1; SMN2PPARAPPARGPTGDR2TSHR | |
| SCHEMBL2210931 | 0.78 | TSHR (0.66) | SMN1; SMN2PPARAPPARGKDM4EPTGDR2 | |
| SCHEMBL2597640 | 0.78 | TSHR (0.66) | SMN1; SMN2PPARAPPARGKDM4EPTGDR2 | |
| SCHEMBL4816920 | 0.78 | PPARA (0.59) | SMN1; SMN2PPARAPPARGKDM4EPTGDR2 | |
| SCHEMBL4777599 | 0.78 | KDM4E (0.49) | SMN1; SMN2KDM4EACHETDP1TSHR | |
| SCHEMBL8935664 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2PPARAPPARGTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091237-B2 | Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |
| US-20040157890-A1 | Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors | GLAXO GROUP LIMITED (GB) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157890-A1 | Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors | PPARG, PPARD, PPARA | SMN1; SMN2 3688/4885PPARA 3/4885PPARG 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.