Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.48 |
| ▸ | PDE4A | P27815 | 6/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143512 | 0.92 | AAK1 (0.52) | PDE4BALDH1A1AAK1MAPTKDM4E | |
| SCHEMBL6603362 | 0.92 | PDE5A (0.54) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL145065 | 0.88 | PDE4A (0.51) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6602823 | 0.88 | AAK1 (0.48) | PDE4BALDH1A1AAK1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7646226 | 0.87 | PDE4D (0.50) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL145758 | 0.87 | PDE5A (0.49) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8208033 | 0.86 | SMN1; SMN2 (0.50) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6601582 | 0.83 | MAOB (0.48) | PDE4BALDH1A1AAK1MAPTPOLB | |
| SCHEMBL6601874 | 0.83 | ABCG2 (0.47) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27557634 | 0.82 | MKNK1 (0.45) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |