Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.49 |
| ▸ | PDE4A | P27815 | 8/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601582 | 0.92 | MAOB (0.48) | PDE4BMEN1KMT2A | |
| SCHEMBL6600972 | 0.92 | PDE5A (0.53) | PDE5APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6600783 | 0.88 | RXFP1 (0.43) | PDE4BMEN1KMT2A | |
| SCHEMBL7646891 | 0.87 | MAOB (0.41) | PDE4BMEN1KMT2A | |
| SCHEMBL6602010 | 0.87 | PDE4B (0.52) | PDE5APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6605978 | 0.86 | PDE5A (0.51) | PDE5APDE4DPDE4BPDE4APDE4C | |
| Hydrochloric Acid SCHEMBL7649060 | 0.86 | PDE4B (0.51) | PDE5APDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6602257 | 0.84 | ALDH1A1 (0.43) | MEN1KMT2A | |
| SCHEMBL143512 | 0.83 | AAK1 (0.52) | PDE4BMEN1KMT2A | |
| SCHEMBL6605566 | 0.82 | CFTR (0.47) | PDE4BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |