Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 6/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603985 | 0.93 | ITGB3 (0.57) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6602680 | 0.93 | ITGB3 (0.48) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6605553 | 0.93 | ITGB3 (0.61) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601381 | 0.90 | ITGB3 (0.59) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6602638 | 0.90 | ITGB3 (0.60) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6600954 | 0.89 | ITGB3 (0.61) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6604752 | 0.89 | ITGB3 (0.59) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601822 | 0.89 | ITGB3 (0.64) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6600986 | 0.89 | ITGB3 (0.64) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601484 | 0.89 | ITGB3 (0.64) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |