Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601380 | 0.88 | PTGS2 (0.79) | PTGS2PTGS1 | |
| SCHEMBL6601664 | 0.87 | PTGS2 (0.75) | PTGS2PTGS1PFKFB3 | |
| SCHEMBL6600842 | 0.83 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL6606371 | 0.82 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL6601421 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1METNTRK1PIM1 | |
| SCHEMBL6602267 | 0.82 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL6602110 | 0.82 | PTGS2 (0.66) | PTGS2PTGS1METNTRK1PIM1 | |
| SCHEMBL6600014 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL6605804 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1PFKFB3 | |
| SCHEMBL6605506 | 0.81 | PTGS2 (0.82) | PTGS2PTGS1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975604-B1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2004-07-21 | — | — | EP | disclosed |
| EP-0975604-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-02-02 | — | — | EP | disclosed |
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | disclosed |
| WO-1998041511-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1998-09-24 | — | — | WO | disclosed |