Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.61 |
| ▸ | JAK2 | O60674 | 4/20 | 0.61 |
| ▸ | JAK1 | P23458 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 9/20 | 0.54 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.54 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063160 | 0.84 | ITGB1 (0.64) | TYK2JAK2JAK1CYP3A4ITGB1 | |
| SCHEMBL27796647 | 0.82 | SMO (0.68) | TYK2JAK2KMT2AKLKB1MAPT | |
| SCHEMBL28097825 | 0.81 | FFAR1 (0.57) | TYK2JAK2JAK1CYP3A4TAS1R3 | |
| SCHEMBL4154853 | 0.80 | TYK2 (0.71) | TYK2JAK2JAK1CYP3A4TAS1R3 | |
| SCHEMBL14532180 | 0.79 | TYK2 (0.65) | TYK2JAK2JAK1CYP3A4TAS1R3 | |
| SCHEMBL95630 | 0.79 | TYK2 (0.65) | TYK2JAK2JAK1CYP3A4TAS1R3 | |
| SCHEMBL678659 | 0.79 | KMT2A (0.67) | TYK2JAK2JAK1CYP3A4TAS1R3 | |
| SCHEMBL7384072 | 0.79 | TYK2 (0.65) | TYK2JAK2JAK1CYP3A4TAS1R3 | |
| SCHEMBL5230799 | 0.78 | ITGB1 (0.64) | ITGB1ITGA4ITGA2ITGB7 | |
| SCHEMBL27515653 | 0.78 | ITGB1 (0.64) | ITGB1ITGA4ITGA2ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066316-B1 | CINNAMIC ACID DERIVATIVES HAVING CELL ADHESION MODULATING ACTIVITY | CELLTECH THERAPEUTICS LTD (GB) | 2004-05-12 | — | — | EP | disclosed |
| US-6329362-B1 | MODULATION CELL ADHESION THE COMPOUNDS ARE ABLE TO INHIBIT THE BINDING OF ALPHA 4 INTEGRINS TO THEIR LIGANDS AND ARE OF USE IN THE PROPHYLAXIS AND TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS. | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |