Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.68 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.58 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381355 | 0.87 | PTGS2 (0.76) | PTGS2PTGS1ITGB1ITGA4ITGB7 | |
| SCHEMBL6601979 | 0.87 | PTGS2 (0.77) | PTGS2PTGS1ITGB1ITGA4ITGB7 | |
| SCHEMBL6603152 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6601509 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1ITGB1ITGA4ITGB7 | |
| SCHEMBL6601374 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6601032 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6599964 | 0.78 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL4186362 | 0.78 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL4191548 | 0.78 | PTGS2 (0.86) | PTGS2PTGS1 | |
| SCHEMBL6601027 | 0.77 | PTGS2 (0.79) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | claimed |
| EP-0975604-B1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2004-07-21 | — | — | EP | disclosed |
| EP-0975604-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-02-02 | — | — | EP | disclosed |
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | disclosed |
| WO-1998041511-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1998-09-24 | — | — | WO | disclosed |