Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.44 |
| ▸ | PDE2A | O00408 | 4/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486842 | 0.92 | PDE3B (0.47) | SIRT2PIN1PDE3BPDE3APDE2A | |
| SCHEMBL6483724 | 0.91 | DPP4 (0.48) | LTB4RPIN1PDE3BPDE3APDE2A | |
| SCHEMBL6484026 | 0.91 | KDM4E (0.51) | LTB4RPIN1PDE3BPDE3APDE2A | |
| SCHEMBL6475593 | 0.90 | PIN1 (0.47) | PIN1PDE3BPDE3APDE2APTGER4 | |
| SCHEMBL6484337 | 0.90 | PIN1 (0.51) | LTB4RPIN1PDE3BPDE3APDE2A | |
| SCHEMBL6484584 | 0.90 | HDAC1 (0.45) | SIRT2PIN1PDE3BPDE3APDE2A | |
| SCHEMBL6480698 | 0.89 | KDM4E (0.48) | LTB4RPIN1PDE3BPDE3APDE2A | |
| SCHEMBL6475279 | 0.88 | PIN1 (0.59) | PIN1PDE3BPDE3APDE2APTGER4 | |
| SCHEMBL6484022 | 0.88 | PDE3B (0.46) | PIN1PDE3BPDE3APDE2APTGER4 | |
| SCHEMBL6484473 | 0.87 | PIN1 (0.47) | PIN1PDE3BPDE3APDE2APTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404321-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | Schering Aktiengesellschaft (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004023-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-16 | — | — | WO | disclosed |