Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.80 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.72 |
| ▸ | PTGIR | P43119 | 2/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601318 | 0.96 | PTGS2 (0.76) | PTGS2PTGS1PTGIRPTGDR | |
| SCHEMBL6601455 | 0.95 | PTGS2 (0.81) | PTGS2PTGS1PTGIRPTGDR | |
| SCHEMBL6599968 | 0.92 | PTGS2 (0.80) | PTGS2PTGS1PTGIRPTGDR | |
| SCHEMBL6600931 | 0.90 | PTGS2 (0.66) | PTGS2PTGS1PTGIR | |
| SCHEMBL4188723 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6601418 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL6601312 | 0.85 | PTGS2 (0.94) | PTGS2PTGS1 | |
| SCHEMBL6601454 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6601167 | 0.84 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL6601107 | 0.84 | PTGS2 (0.56) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975604-B1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2004-07-21 | — | — | EP | claimed |
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | claimed |
| EP-0975604-B1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2004-07-21 | — | — | EP | disclosed |
| EP-0975604-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-02-02 | — | — | EP | disclosed |
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | disclosed |
| WO-1998041511-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1998-09-24 | — | — | WO | disclosed |