Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.78 |
| ▸ | HTR2C | P28335 | 14/20 | 0.78 |
| ▸ | HTR2B | P41595 | 13/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602349 | 1.00 | HTR2A (0.78) | HTR2AHTR2CHTR2BL3MBTL1CCR1 | |
| SCHEMBL906124 | 0.88 | HTR2A (1.00) | HTR2AHTR2CHTR2BL3MBTL1CCR1 | |
| Fumaric Acid SCHEMBL6603600 | 0.82 | HTR2A (0.82) | HTR2AHTR2CHTR2BL3MBTL1CYP3A4 | |
| Fumaric Acid SCHEMBL6603599 | 0.82 | HTR2A (0.82) | HTR2AHTR2CHTR2BL3MBTL1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL906126 | 0.80 | HTR2A (0.70) | HTR2AHTR2CHTR2BL3MBTL1CCR1 | |
| SCHEMBL6602404 | 0.77 | HTR2A (0.76) | HTR2AHTR2CHTR2BKDM4ELMNA | |
| SCHEMBL4826871 | 0.77 | HTR2A (0.76) | HTR2AHTR2CHTR2BKDM4ELMNA | |
| SCHEMBL4826880 | 0.77 | HTR2A (0.76) | HTR2AHTR2CHTR2BKDM4ELMNA | |
| SCHEMBL906125 | 0.71 | HTR2A (0.61) | HTR2AHTR2CHTR2BL3MBTL1CCR1 | |
| SCHEMBL6604187 | 0.66 | HTR2A (0.75) | HTR2AHTR2CHTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |