Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 15/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 15/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601023 | 0.88 | KCNE1 (0.53) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6605946 | 0.88 | KCNE1 (0.55) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6600854 | 0.86 | KCNE1 (0.46) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6559307 | 0.85 | KCNE1 (0.59) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6558631 | 0.85 | KCNE1 (0.46) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6559490 | 0.83 | KCNE1 (0.45) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6601750 | 0.82 | KCNE1 (0.43) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6601126 | 0.82 | KCNE1 (0.68) | KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL6600820 | 0.81 | KCNE1 (0.47) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6558707 | 0.80 | KCNE1 (0.45) | KCNE1KCNQ1KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906911-B1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2004-04-28 | — | — | EP | disclosed |
| EP-0906911-A1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-07 | — | — | EP | disclosed |