Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 14/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 14/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 14/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 14/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 11/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 11/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 11/20 | 0.42 |
| ▸ | GRIK4 | Q16099 | 11/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602512 | 0.90 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6605459 | 0.88 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6602507 | 0.86 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Hydrochloric Acid SCHEMBL6603295 | 0.75 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6605330 | 0.71 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6378080 | 0.71 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6604533 | 0.69 | GRIA1 (0.61) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6604215 | 0.68 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6593784 | 0.65 | GRIA1 (0.83) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6376380 | 0.64 | HSD17B10 (0.34) | GRIA1GRIA2GRIA3GRIA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020453-B1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6348461-B1 | CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1020453-A1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |