Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602624 | 0.90 | NPSR1 (0.54) | MCHR1NPSR1HTR2CMAPK1MAPT | |
| SCHEMBL6603061 | 0.89 | NPSR1 (0.54) | MCHR1NPSR1HTR2CMAPK1MAPT | |
| SCHEMBL6602613 | 0.88 | MCHR1 (0.66) | MCHR1HTR2CMAPK1MAPTSCD | |
| SCHEMBL6604994 | 0.86 | NPSR1 (0.55) | MCHR1NPSR1MAPK1MAPTLMNA | |
| SCHEMBL6604146 | 0.84 | MCHR1 (0.51) | MCHR1HTR2CKDM4E | |
| SCHEMBL6603803 | 0.82 | MCHR1 (0.63) | MCHR1NPSR1HTR2CMAPTLMNA | |
| SCHEMBL6607021 | 0.82 | MCHR1 (0.54) | MCHR1HTR2CMAPK1MAPTLMNA | |
| SCHEMBL6602778 | 0.80 | MCHR1 (0.49) | MCHR1NPSR1HTR2CMAPTKDM4E | |
| SCHEMBL6615547 | 0.79 | MCHR1 (0.49) | MCHR1HTR2CMAPTKDM4E | |
| SCHEMBL6606577 | 0.78 | ALDH1A1 (0.53) | MCHR1MAPK1MAPTSCDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | claimed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |