Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.98 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856436 | 0.81 | MAPK14 (0.67) | MAPK14MAPK11NPC1RAB9AMAP2K1 | |
| SCHEMBL5659598 | 0.81 | MAPK14 (0.67) | MAPK14MAPK11NPC1RAB9AMAP2K1 | |
| SCHEMBL4860601 | 0.80 | MAPK14 (0.65) | MAPK14MAPK11LCKMAP2K1 | |
| SCHEMBL6605697 | 0.79 | MAPK14 (0.71) | MAPK14MAPK11LCK | |
| SCHEMBL12345132 | 0.79 | MAPK14 (0.62) | MAPK14NPC1RAB9ATSHRMEN1 | |
| SCHEMBL4861254 | 0.78 | MAPK14 (0.67) | MAPK14MAPK11LCKMAP2K1 | |
| SCHEMBL4860460 | 0.78 | MAPK14 (0.63) | MAPK14MAPK11LCKMAP2K1 | |
| SCHEMBL4865916 | 0.78 | MAPK14 (0.67) | MAPK14MAPK11LCKMAP2K1 | |
| SCHEMBL6604150 | 0.78 | MAPK14 (0.75) | MAPK14MAPK11LCK | |
| SCHEMBL2906631 | 0.77 | PLA2G7 (0.62) | MAPK14NPC1RAB9ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436269-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |