Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934489 | 0.84 | AURKA (0.46) | DYRK1APRKCIAHRPIK3CDPIK3CB | |
| SCHEMBL20412219 | 0.79 | MAPK10 (0.37) | CLK1DYRK1APRKCIPIK3CDPIK3CB | |
| SCHEMBL20412216 | 0.78 | CLK1 (0.41) | CLK1DYRK1APRKCIPIK3CDPIK3CB | |
| SCHEMBL1159186 | 0.76 | PARP1 (0.53) | CLK1DYRK1ATNFMAPT | |
| SCHEMBL29569821 | 0.75 | CLK1 (0.54) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL672509 | 0.75 | CLK1 (0.54) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL10594346 | 0.73 | TNF (0.43) | AHRTNFRIPK1KDM4E | |
| SCHEMBL11189722 | 0.72 | MAPT (0.43) | CLK1DYRK1ATNFMAPK10HIPK2 | |
| SCHEMBL450386 | 0.72 | EGFR (0.40) | DYRK1AAHRPIK3CDTNFRIPK1 | |
| SCHEMBL30617074 | 0.72 | KDM4A (0.46) | CLK1DYRK1APRKCITNFMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9566273-B2 | Nicotinic attenuation of CNS inflammation and autoimmunity | DIGNITY HEALTH (US) | 2017-02-14 | — | — | US | disclosed |
| US-20140364463-A1 | NICOTINIC ATTENUATION OF CNS INFLAMMATION AND AUTOIMMUNITY | DIGNITY HEALTH (US) | 2014-12-11 | — | — | US | disclosed |
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |