SCHEMBL450386

SCHEMBL450386

c1ncc2c(ccc3cc[nH]c32)n1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EGFR P00533 12/20 0.40
DYRK1A Q13627 1/20 0.38
AHR P35869 1/20 0.36
TDO2 P48775 2/20 0.35
TNF P01375 1/20 0.34
RIPK1 Q13546 1/20 0.34
IKBKB O14920 1/20 0.34
CHUK O15111 1/20 0.34
PIK3CD O00329 1/20 0.32
PIK3CA P42336 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16896218 0.98 EGFR (0.39) EGFRDYRK1AAHRTDO2TNF
SCHEMBL11275324 0.82 EGFR (0.36) EGFRDYRK1AAHRTDO2IKBKB
SCHEMBL30949930 0.75 MAPT (0.40) EGFRPIK3CA
SCHEMBL28575817 0.75 MAPT (0.40) EGFRPIK3CA
SCHEMBL23852799 0.74 AHR (0.38) EGFRDYRK1AAHRTDO2TNF
SCHEMBL3403480 0.74 KDM4A (0.37) EGFRTDO2
SCHEMBL7744422 0.74 EGFR (0.36) EGFRTDO2PIK3CDPIK3CA
SCHEMBL7744423 0.74 AHR (0.35) AHRTNFRIPK1
SCHEMBL30917344 0.73 TDO2 (0.39) EGFRDYRK1AAHRTDO2PIK3CD
SCHEMBL8565229 0.73 AHR (0.37) EGFRAHRTNFRIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 702 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132377-A1 HEMATOPOIETIC STEM CELL PROLIFERATION MEDIUM AND USE OF THE SAME FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE (TW) 2026-05-14 US claimed
US-12584149-B2 Nuclease-mediated genome editing of primary cells and related kits THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-03-24 US claimed
EP-4692332-A1 PRODUCTION METHOD FOR MEGAKARYOCYTES Otsuka Pharmaceutical Co., Ltd. (JP) 2026-02-11 EP claimed
EP-4673532-A1 THERAPY Plasticell Limited (GB) 2026-01-07 EP claimed
WO-2025080736-A2 ORGANOID CULTURE OF BONE MARROW WITH EXPANSION OF CONSTITUENT NORMAL AND MALIGNANT HEMATOPOIETIC CELLS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2025-04-17 WO claimed
CN-119677841-A Preparation method of dendritic cell progenitor cells and culture medium thereof 浙江吉量科技有限公司 2025-03-21 CN claimed
WO-2025028606-A1 CULTURE MEDIUM FOR HUMAN CELLS, AND METHOD FOR CULTURING HUMAN HEMATOPOIETIC STEM CELLS 国立大学法人筑波大学 2025-02-06 WO claimed
WO-2024210126-A1 PRODUCTION METHOD FOR MEGAKARYOCYTES 大塚製薬株式会社 2024-10-10 WO claimed
US-20240327791-A1 METHODS OF T CELL PRODUCTION ADAPTIMMUNE LIMITED (GB) 2024-10-03 US claimed
WO-2024180345-A1 THERAPY PLASTICELL LTD (GB) 2024-09-06 WO claimed
US-20180147239-A1 METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF HEMA-QUEBEC (CA) 2018-05-31 US claimed
EP-3303570-A1 METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF Héma-Québec (CA) 2018-04-11 EP claimed
EP-3247808-A1 POINT-OF-CARE AND/OR PORTABLE PLATFORM FOR GENE THERAPY Fred Hutchinson Cancer Research Center (US) 2017-11-29 EP claimed
WO-2017185179-A1 METHODS AND COMPOSITIONS FOR EXPANSION OF HEMATOPOIETIC STEM AND/OR PROGENITOR CELLS EMPLOYING A CYTOCHROME P450 1B1 (CYP1B1) INHIBITOR OR A MUSASHI-2 (MSI2) ACTIVATOR MCMASTER UNIVERSITY (CA) 2017-11-02 WO claimed
WO-2017053729-A1 NUCLEASE-MEDIATED GENOME EDITING OF PRIMARY CELLS AND ENRICHMENT THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2017-03-30 WO claimed
WO-2016191879-A1 METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF Héma-Québec (CA) 2016-12-08 WO claimed
WO-2016118780-A1 POINT-OF-CARE AND/OR PORTABLE PLATFORM FOR GENE THERAPY FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2016-07-28 WO claimed
WO-2006100479-A1 METHODS FOR THE SYNTHESIS OF HETEROAROMATIC COMPOUNDS UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2006-09-28 WO claimed
EP-0240176-B1 SUBSTITUTED PYRIMIDOINDOLES JOHN WYETH & BROTHER LIMITED (GB) 1990-11-22 EP claimed
EP-0240176-A1 Substituted pyrimidoindoles JOHN WYETH & BROTHER LIMITED (GB) 1987-10-07 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240327791-A1 METHODS OF T CELL PRODUCTION ICOS, CD4, PBK EGFR 4214/4885DYRK1A 3812/4885AHR 218/4885
US-20260132377-A1 HEMATOPOIETIC STEM CELL PROLIFERATION MEDIUM AND USE OF THE SAME HGF, IGFBP1, IGF1R EGFR 296/4885DYRK1A 4034/4885AHR 4/4885
US-12584149-B2 Nuclease-mediated genome editing of primary cells and related kits ADAR, RNASE1, CPSF6 EGFR 3479/4885DYRK1A 2709/4885AHR 4146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.