⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28872401 | 0.77 | — | — | |
| SCHEMBL29015304 | 0.77 | — | — | |
| SCHEMBL5148314 | 0.77 | — | — | |
| SCHEMBL25181953 | 0.72 | KDM1A (0.36) | — | |
| SCHEMBL149390 | 0.71 | — | — | |
| SCHEMBL261271 | 0.67 | — | — | |
| SCHEMBL1101277 | 0.67 | — | — | |
| SCHEMBL1100275 | 0.67 | — | — | |
| SCHEMBL6561427 | 0.65 | — | — | |
| SCHEMBL972733 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104119285-B | Compound and application thereof as estrogen-related receptor modulator | 中国科学院广州生物医药与健康研究院 | 2016-06-29 | — | — | CN | claimed |
| CN-104119285-A | Compound used as estrogen-related receptor regulator and application of compound | GUANGZHOU INST BIOMED & HEALTH | 2014-10-29 | — | — | CN | claimed |
| EP-3802549-B1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN LA ROCHE (CH) | 2023-03-01 | — | — | EP | disclosed |
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| US-20210238197-A1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2021-08-05 | — | — | US | disclosed |
| EP-3802549-A1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-04-14 | — | — | EP | disclosed |
| CN-112204037-A | Novel oxoquinolizine compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2021-01-08 | — | — | CN | disclosed |
| WO-2019228940-A1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-05 | — | — | WO | disclosed |
| CN-110475777-A | For treating and preventing new pyrido [2,3-b] benzazolyl compounds of bacterium infection | HOFFMANN LA ROCHE | 2019-11-19 | — | — | CN | disclosed |
| CN-107635994-A | Imidazopyrimidine and imidazo-triazine derivative and include its pharmaceutical composition | 爱思开生物制药株式会社 | 2018-01-26 | — | — | CN | disclosed |
| CN-107074810-A | It is used as the tetrahydropyridine of 2 amino 5,5 difluoro 6 (methyl fluoride) 6 phenyl 3,4,5,6 of BACE1 inhibitor | H.隆德贝克有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104119285-B | Compound and application thereof as estrogen-related receptor modulator | 中国科学院广州生物医药与健康研究院 | 2016-06-29 | — | — | CN | disclosed |
| CN-104119285-A | Compound used as estrogen-related receptor regulator and application of compound | GUANGZHOU INST BIOMED & HEALTH | 2014-10-29 | — | — | CN | disclosed |
| CN-103221403-A | Heterocyclic compounds and their use | AMGEN INC | 2013-07-24 | — | — | CN | disclosed |
| US-6800630-B2 | CYTOSTATIC ACTIVITY, INHIBITORY ACTIVITY AGAINST A SIGNAL DERIVED FROM RAS ONCOGENE PRODUCTS | SHIONOGI & CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| EP-1251129-B1 | PYRIMIDINE DERIVATIVES HAVING ANTITUMOR EFFECT | SHIONOGI & CO (JP) | 2004-06-09 | — | — | EP | disclosed |
| US-20030203894-A1 | Pyrimidine derivatives having antitumor effect | SHIONOGI & CO., LTD. (JP) | 2003-10-30 | — | — | US | disclosed |
| EP-1251129-A1 | PYRIMIDINE DERIVATIVES HAVING ANTITUMOR EFFECT | SHIONOGI & CO., LTD. (JP) | 2002-10-23 | — | — | EP | disclosed |
| US-6420367-B1 | RAS GENE | SHIONOGO & CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1097933-A1 | PYRIMIDINE DERIVATIVES EXHIBITING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |