Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.40 |
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616391 | 0.98 | TYK2 (0.40) | TYK2JAK2JAK1CRACR2AITGB1 | |
| SCHEMBL6604492 | 0.92 | CRACR2A (0.39) | TYK2JAK2JAK1CRACR2AITGB1 | |
| SCHEMBL6619499 | 0.91 | CHRM5 (0.40) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6605166 | 0.91 | TYK2 (0.43) | TYK2JAK2JAK1CRACR2AITGB1 | |
| SCHEMBL6603775 | 0.87 | TYK2 (0.41) | TYK2JAK2JAK1CRACR2AITGB1 | |
| SCHEMBL6609028 | 0.86 | TYK2 (0.43) | TYK2JAK2JAK1CRACR2AITGB1 | |
| SCHEMBL6616176 | 0.86 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6620323 | 0.85 | TYK2 (0.41) | TYK2JAK2JAK1CRACR2AITGB1 | |
| SCHEMBL6616599 | 0.85 | KMT2A (0.43) | — | |
| SCHEMBL6615819 | 0.85 | NPSR1 (0.40) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |