Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 9/20 | 1.00 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604176 | 0.90 | PTGS2 (0.81) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL6601382 | 0.90 | PTGS2 (0.81) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL4194004 | 0.87 | PTGS2 (0.83) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL7518362 | 0.82 | PTGS2 (0.78) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL4190199 | 0.81 | PTGS2 (0.73) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL4190505 | 0.81 | PTGS2 (0.89) | PTGS2PTGS1 | |
| SCHEMBL4184783 | 0.80 | PTGS2 (1.00) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL4182604 | 0.80 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL4190198 | 0.80 | PTGS2 (1.00) | PTGS2PTGS1NPBWR1 | |
| SCHEMBL6602110 | 0.80 | PTGS2 (0.66) | PTGS2PTGS1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975604-B1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2004-07-21 | — | — | EP | claimed |
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | claimed |
| EP-0975604-B1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2004-07-21 | — | — | EP | disclosed |
| EP-0975604-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-02-02 | — | — | EP | disclosed |
| US-6004960-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANTIPYRETICS, ANALGESICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | disclosed |
| WO-1998041511-A1 | PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1998-09-24 | — | — | WO | disclosed |