Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604316 | 0.88 | CDK2 (0.50) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL6604517 | 0.88 | CDK2 (0.44) | CDK2CDK4CCNA2CCNA1 | |
| SCHEMBL6605982 | 0.87 | CDK2 (0.49) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL6387033 | 0.84 | CDK2 (0.50) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL4021385 | 0.82 | CDK2 (0.48) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL6604728 | 0.81 | CDK2 (0.48) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL5098992 | 0.80 | CDK2 (0.60) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL5095293 | 0.79 | CDK2 (0.59) | CDK2CDK4CCNA2CCNA1SLC12A2 | |
| SCHEMBL6609742 | 0.79 | CDK2 (0.63) | CDK2CDK4SYK | |
| SCHEMBL6598183 | 0.78 | CDK2 (0.64) | CDK2CDK4CCNA2CCNA1SLC12A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |