Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | CDK4 | P11802 | 5/20 | 0.44 |
| ▸ | IKBKB | O14920 | 5/20 | 0.42 |
| ▸ | STK4 | Q13043 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603729 | 0.88 | CDK2 (0.51) | CDK2CDK4CCNA2CCNA1 | |
| SCHEMBL6606468 | 0.86 | CDK2 (0.44) | CDK2CDK4IKBKBSTK4CNR1 | |
| SCHEMBL6609742 | 0.84 | CDK2 (0.63) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL5108295 | 0.77 | CDK2 (0.56) | CDK2CDK4STK4GSK3BCCNT1 | |
| SCHEMBL6598505 | 0.77 | CDK2 (0.72) | CDK2CDK4GSK3BCCNT1CDK1 | |
| SCHEMBL6604144 | 0.76 | CDK2 (0.55) | CDK2CDK4IKBKBGSK3BCDK1 | |
| SCHEMBL6104318 | 0.75 | CDK2 (0.71) | CDK2CDK4STK4GSK3BCCNT1 | |
| SCHEMBL6604316 | 0.75 | CDK2 (0.50) | CDK2CDK4CCNA2CCNA1 | |
| SCHEMBL6103961 | 0.74 | CDK2 (0.72) | CDK2CDK4GSK3BCCNT1CDK1 | |
| SCHEMBL6605982 | 0.73 | CDK2 (0.49) | CDK2CDK4CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | claimed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | claimed |
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |