Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.63 |
| ▸ | PPARG | P37231 | 15/20 | 0.63 |
| ▸ | RARG | P13631 | 7/20 | 0.56 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | RXRG | P48443 | 4/20 | 0.45 |
| ▸ | RARA | P10276 | 3/20 | 0.45 |
| ▸ | RARB | P10826 | 3/20 | 0.45 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.40 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606079 | 1.00 | RXRA (0.63) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6060453 | 0.88 | RXRA (0.80) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL7745973 | 0.88 | RXRA (0.80) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL7745977 | 0.88 | RXRA (0.80) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6606945 | 0.81 | RXRA (0.61) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6605468 | 0.81 | RXRA (0.68) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL4135046 | 0.78 | RXRA (0.81) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL4135043 | 0.78 | RXRA (0.81) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL4135030 | 0.78 | RXRA (0.81) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6449663 | 0.78 | RXRA (0.66) | RXRAPPARGRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161410-B1 | RETINOID ANTAGONISTS AND USE THEREOF | BASILEA PHARMACEUTICA AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| CN-1337931-A | Retinoid antagonists and use thereof | DASLIA PHARMACEUTICAL CO LTD (CH) | 2002-02-27 | — | — | CN | disclosed |
| US-6326397-B1 | OSTEOPOROSIS | HOFFMAN-LA ROCHE INC. | 2001-12-04 | — | — | US | disclosed |