Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 14/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603759 | 1.00 | TACR2 (0.47) | TACR2CCR5TACR1 | |
| SCHEMBL756561 | 0.86 | TACR2 (0.46) | TACR2CCR5TACR1 | |
| SCHEMBL4870085 | 0.86 | TACR2 (0.46) | TACR2CCR5TACR1 | |
| SCHEMBL6666159 | 0.85 | TACR2 (0.52) | TACR2TACR1 | |
| SCHEMBL6666154 | 0.85 | TACR2 (0.52) | TACR2TACR1 | |
| SCHEMBL4873822 | 0.80 | TACR2 (0.70) | TACR2TACR1 | |
| SCHEMBL4610521 | 0.80 | TACR2 (0.70) | TACR2TACR1 | |
| SCHEMBL8870644 | 0.80 | TACR2 (0.70) | TACR2TACR1 | |
| SCHEMBL7315171 | 0.80 | TACR2 (0.45) | TACR2CCR5TACR1 | |
| SCHEMBL6595201 | 0.79 | TACR2 (0.50) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |