Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 15/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756561 | 0.93 | TACR2 (0.46) | TACR2TACR1CCR5 | |
| SCHEMBL4870085 | 0.93 | TACR2 (0.46) | TACR2TACR1CCR5 | |
| SCHEMBL759265 | 0.87 | TACR2 (0.44) | TACR2TACR1CCR5 | |
| SCHEMBL7306571 | 0.85 | TACR2 (0.40) | TACR2TACR1CCR5 | |
| SCHEMBL8483223 | 0.85 | TACR2 (0.41) | TACR2TACR1CCR5 | |
| SCHEMBL4610589 | 0.83 | TACR2 (0.39) | TACR2TACR1CCR5 | |
| SCHEMBL4865304 | 0.83 | TACR2 (0.39) | TACR2TACR1CCR5 | |
| SCHEMBL756560 | 0.81 | ALDH1A1 (0.35) | TACR2 | |
| SCHEMBL8559300 | 0.81 | F2R (0.52) | TACR2 | |
| SCHEMBL6603754 | 0.80 | TACR2 (0.47) | TACR2TACR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294537-B1 | NEUROKININS USED FOR TREATMENT OF DISEASES | SANOFI-SYNTHELABO (FR) | 2001-09-25 | — | — | US | disclosed |
| US-6124316-A | ACTIVE DRUG TREATING PSYCHIATRIC DISEASES, DISEASES OF PSYCHOSOMATIC ORIGIN, OF HYPERTENSION AND, NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 2000-09-26 | — | — | US | disclosed |
| US-5942523-A | NOVEL PIPERIDINE DERIVATIVES WHOSE SPECIFIC STRUCTURE INCLUDES AT POSITION 1 AN ALKYL CHAIN HAVING A 3,4-DICHLOROPHENYL GROUP ATTACHED; HIGH SELECTIVITY TO THE NK3 RECEPTOR; UNIT DOSAGE FORM; TREATING PSYCHIATRIC DISEASES | SANOFI (FR) | 1999-08-24 | — | — | US | disclosed |
| US-5741910-A | PIPERIDINE DERIVATIVE INTERMEDIATES | SANOFI (FR) | 1998-04-21 | — | — | US | disclosed |
| EP-0673928-A1 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists | SANOFI (FR) | 1995-09-27 | — | — | EP | disclosed |