Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL9978894 | 1.00 | CSNK1A1 (0.42) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 | |
| Piperazine SCHEMBL28251008 | 0.93 | CSNK1A1 (0.39) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 | |
| SCHEMBL34651 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL4023730 | 0.86 | NPC1 (0.47) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 | |
| SCHEMBL9786602 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL4244388 | 0.86 | — | — | |
| Pyridine SCHEMBL6603492 | 0.85 | KMT2A (0.45) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 | |
| Biphenyl SCHEMBL27718930 | 0.84 | CSNK1A1 (0.49) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 | |
| Pyrrole SCHEMBL1577642 | 0.83 | CSNK1A1 (0.44) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 | |
| SCHEMBL25335480 | 0.81 | CSNK1A1 (0.42) | CSNK1A1TYRO3DYRK1BKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023291-B1 | DIPYRIDOIMIDAZOLDERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-1023291-A1 | DIPYRIDOIMIDAZOLDERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| US-5968946-A | FUSED PYRROLO-IMIDAZOPYRIDINE DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1999040092-A1 | OXO-DIPYRIDOIMIDAZOLE-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-08-12 | — | — | WO | disclosed |
| WO-1999018105-A1 | DIPYRIDOIMIDAZOLDERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-04-15 | — | — | WO | disclosed |