Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CD38 | P28907 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025727 | 0.83 | TRPV1 (0.66) | TRPV1PKMROCK2ROCK1ALDH1A1 | |
| SCHEMBL4023559 | 0.78 | TRPV1 (0.67) | TRPV1PKMCD38ROCK2ROCK1 | |
| SCHEMBL4021114 | 0.77 | TRPV1 (0.63) | TRPV1PKMROCK2ROCK1TSHR | |
| SCHEMBL6441785 | 0.76 | TRPV1 (0.60) | TRPV1PKMROCK2ROCK1TSHR | |
| SCHEMBL2727166 | 0.73 | TRPV1 (0.61) | TRPV1P2RX7 | |
| SCHEMBL6066195 | 0.73 | TRPV1 (0.61) | TRPV1PKMCD38ROCK2ROCK1 | |
| SCHEMBL1932253 | 0.70 | NPC1 (0.64) | TRPV1ROCK2ROCK1ALDH1A1IDH1 | |
| SCHEMBL6441790 | 0.69 | TSHR (0.45) | TRPV1PKMALDH1A1TSHRP2RX7 | |
| SCHEMBL6066217 | 0.69 | TRPV1 (0.58) | TRPV1P2RX7 | |
| SCHEMBL697972 | 0.68 | ALDH1A1 (0.63) | ALDH1A1TSHRNPC1RAB9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070247-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | disclosed |