Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521073 | 0.81 | TACR1 (0.54) | KMT2AMEN1MC4RNPY5RSMN1; SMN2 | |
| SCHEMBL6156128 | 0.81 | AKT1 (0.57) | MC4RNPY5RSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4504452 | 0.81 | AKT1 (0.57) | MC4RNPY5RSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4514596 | 0.81 | AKT1 (0.57) | MC4RNPY5RSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4519175 | 0.79 | MC4R (0.59) | KMT2AMEN1MC4RNPY5RSMN1; SMN2 | |
| SCHEMBL4524771 | 0.79 | TACR1 (0.65) | MC4RNPY5RSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4520314 | 0.78 | MC4R (0.53) | MC4RNPY5RSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6603964 | 0.77 | NPY5R (0.55) | KMT2AMEN1MAPTNPY5RSMN1; SMN2 | |
| SCHEMBL4682083 | 0.77 | TACR1 (0.55) | MC4RNPY5RSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4505547 | 0.77 | LMNA (0.56) | MC4RNPY5RSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |