Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445 | 0.81 | TSHR (0.44) | LPAR1LPAR3 | |
| SCHEMBL11123 | 0.78 | LPAR1 (0.40) | LPAR1LPAR3TRPV1MAPTKDM4E | |
| SCHEMBL7104 | 0.77 | LPAR1 (0.34) | LPAR1LPAR3MEN1KMT2ALMNA | |
| SCHEMBL18597709 | 0.72 | LPAR1 (0.40) | LPAR1LPAR3MEN1KMT2ATRPV1 | |
| SCHEMBL1166 | 0.71 | LPAR1 (0.47) | LPAR1LPAR3LMNAMAPTKDM4E | |
| SCHEMBL7303 | 0.71 | CYP2A6 (0.38) | LPAR1LPAR3MEN1KMT2ALMNA | |
| SCHEMBL2106 | 0.70 | MAPT (0.39) | LPAR1LPAR3LMNATRPV1MAPT | |
| SCHEMBL6478 | 0.70 | LPAR1 (0.38) | LPAR1LPAR3MEN1KMT2ALMNA | |
| SCHEMBL4348 | 0.70 | IGF1R (0.43) | LPAR1LPAR3LMNAMAPTKDM4E | |
| SCHEMBL6761 | 0.69 | LPAR1 (0.38) | LPAR1LPAR3MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |